Clin Case Rep Int | Volume 4, Issue 1 | Case Report | Open Access
Mastura Monif1,5,6*, Michael Christie2, Mark Marriott1, Katherine J Drummond3 and Lynette Chee4
1Department of Neurology, Royal Melbourne Hospital, Australia 2Department of Pathology, Royal Melbourne Hospital, Australia 3Department of Neurosurgery, Royal Melbourne Hospital, Australia 4Department of Clinical Hematology and BMT Service, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Australia 5Department of Physiology, The University of Melbourne, Australia 6Department of Neuroscience, Monash University, Australia
*Correspondance to: Mastura MonifFulltext PDF
Primary CNS Lymphoma (PCNSL) of the choroid plexus is a very rare tumor. Its clinical and radiological manifestations are not entirely clear due to the rarity of the disease; and hence diagnosis of this condition can be delayed due lack of knowledge associated with the disease. We present a case of a 63-year-old man who presented with a few weeks of cognitive deficits with dysphasia and marked impairments in short term memory. His MRI brain showed subtle FLAIR and T1 contrast abnormalities near the lateral ventricles abutting the temporal lobe at the choroid plexus. On brain biopsy he was noted to have perivascular atypical B lymphocytes consistent with PCNSL. High-dose methotrexate, teniposide, BCNU, prednisolone and Rituximab, followed by 5 months of consolidative chemotherapy with cytarabine resulted in clinical and radiological improvement. He subsequently relapsed twice and salvage chemotherapy with consolidative radiotherapy was delivered. Unfortunately, 6 months later his condition worsened and he was referred to palliative care, and then deceased. PCNSL of the choroid plexus is very rare and cases of relapsed disease generally have poor outcome despite a variety of chemo and radiotherapy options. Targeted therapies with optimal penetration of the blood brain barrier are warranted.
Primary CNS lymphoma; Choroid plexus; Brain malignancy
Monif M, Christie M, Marriott M, Drummond KJ, Chee L. A Case Report of Primary CNS Lymphoma of Choroid Plexus. Clin Case Rep Int. 2020; 4: 1171.