Glomus Tumor of the Female Genital Tract: Three Cases and Literature Review

Jing Q, Jiang W, Liu T, Li L, Zou J* and Feng M*

Department of Pathology, West China Second University Hospital, China

^*Correspondance to: Juan Zou 

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Abstract:

Glomus tumors are unusual, benign tumors usually located in the deep dermis of the extremities, while extremely rare cases are in the female genital tract. Here we report 3 cases of glomus tumor of the female genital tract and review the literature. Case 1 was a 32-year-old woman who presented with vaginal tenderness and dyspareunia of one year and a mass with a 1.0 cm diameter was found. Case 2 was a 45-year-old woman who had a 4 cm, movable nodule in the left labia majora. Case 3 was a 56-year-old woman who presented with a mobile, painless nodule with a diameter of 0.8 cm in the right labia majora for one month. All three patients underwent local excision. The tumor cells of all three patients showed epithelioid and no miotic figures or nuclear atypia. The tumor cells of case one expressed vimentin, caldesmon, calponin, SMA, and CD34; those of case two expressed vimentin and were focally positive for actin and collagen IV; and those of case three expressed SMA and vimentin, with focal positivity for CD99 and calponin. Case one and case three were diagnosed as glomus tumors and case two was diagnosed as glomus tumor with uncertain malignant potential based on the morphology and immunohistochemical results. Through these cases and a literature review, this report will expand our understanding of the glomus tumors in the female genital tract. Especially for intraoperative frozen sections, the possibility of this tumor needs to be considered to prevent over diagnosis or overtreatment.

Keywords:

Glomus tumor; Vagina; Vulva; Immunohistochemistry; Frozen Section

Cite the Article:

Jing Q, Jiang W, Liu T, Li L, Zou J, Feng M. Glomus Tumor of the Female Genital Tract: Three Cases and Literature Review. Clin Case Rep Int. 2022; 6: 1285.