Journal Basic Info
- Impact Factor: 0.285**
- H-Index: 6
- ISSN: 2638-4558
- DOI: 10.25107/2638-4558
Major Scope
- Nursing
- Ophthalmology
- Breast Neoplasms
- ENT
- Pneumonia
- Dentistry and Oral Medicine
- Emergency Medicine and Critical Care
- Surgical
Abstract
Citation: Clin Case Rep Int. 2022;6(1):1311.DOI: 10.25107/2638-4558.1311
Simultaneous Spleno-Pancreatectomy and Mini-ALPPS Approach for the Treatment of Metastatic Functional Gastrinoma
Cecilia Jorge
Italian Hospital of Buenos Aires, Argentina
*Correspondance to: Cecilia Jorge
PDF Full Text Case Report | Open Access
Abstract:
Background: Gastrinomas are rare functional neuroendocrine tumors primarily located in the duodenum or pancreas, causing Zollinger-Ellison syndrome. At presentation, up to 25% of gastrinomas are metastasized, predominantly to the liver. The presence of liver metastases has a negative impact on the prognosis. Liver resection for neuroendocrine metastases is associated to long-term survival advantages and disease control. Nevertheless, the benefits of aggressive liver resection should be weighed against the potential risk of post-hepatectomy liver failure. Summary: This report presents the case of a 41-year-old female patient who presented severe diarrhea due to a pancreatic functional gastrinoma with synchronic hepatic metastases. Preoperative assessment of future liver remnant function through a newly developed dynamic measure calculated using hepatobiliary scintigraphy -HIBA index- is described. The present case report also underlines a two-stage surgical management consisting of Mini-ALPPS procedure, distal pancreatectomy and splenectomy which allowed primary and secondary lesions to be fully resected. Conclusion: Liver metastatic pancreatic neuroendocrine tumors can be approached through an aggressive R0 resection with curative intent as long as a meticulous appraisal of future liver remnant function is conducted to ensure the patient's postoperative safe and uneventful recovery.
Keywords:
Gastrinoma; Pancreas; Liver metastases; Hepatectomy; Future liver remnant
Cite the Article:
Jorge C. Simultaneous Spleno- Pancreatectomy and Mini-ALPPS Approach for the Treatment of Metastatic Functional Gastrinoma. Clin Case Rep Int. 2022; 6: 1311.