ACE2 Gene Polymorphisms Associated with COVID-19 Infection Susceptibility to Cardiovascular Disease

Sundaramoorthy A, Hemachandran K and Shanmugam N

Department of Biomedical Science, Bharathidasan University, India
Department of Zoology, Sri Moogambigai College of Arts and Science for Women, India

^*Correspondance to: Narkunaraja Shanmugam 

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Abstract:

COVID-19, caused by SARS-CoV-2, was an emerging pandemic in December 2019 and was first reported by officials in Wuhan City, China. The Angiotensin-Converting Enzyme 2 (ACE2) is the main host cell receptor of human pathogenic SARS-CoV-2 and it plays a crucial role in the entry of the virus into the cell to cause and finally COVID-19 infection. We review the possible association of ACE2 gene polymorphisms in COVID-19 along with the risk of cardiovascular disease. From the year 2020 onwards number of researchers reported ACE2 main functional role in simulations has indicated several of these polymorphisms could affect interactions of SARS-CoV-2 and explained the concept of partial explanation for the regional differences and the disease severity. Here, we discuss the potential effect of polymorphisms of the ACE2 gene in the main function of plasma ACE2 activity in myocardial infarction, ischemic heart disease, and hypertension. Furthermore, we speculate on the potential role of ACE2 gene polymorphisms of rs2285666 as a common genetic locus and susceptibility marker for the COVID-19 infection that might be associated with cardiovascular disease risk.

Keywords:

ACE2 polymorphism; Cardiovascular risk; COVID-19; Genetic susceptibility

Cite the Article:

Sundaramoorthy A, Hemachandran K, Shanmugam N. ACE2 Gene Polymorphisms Associated with COVID-19 Infection Susceptibility to Cardiovascular Disease. Clin Case Rep Int. 2022; 6: 1349.