Bilateral Facial Palsy and Rapid Cognitive Decline Indicating Lymphomatosis cerebri: A Case Report

Waltener M, Hanseeuw B, Benjamin L, Hugues J and Sibille FX

Department of Neurology, CHU UCL Namur, Belgium
Department of Neurology, Saint-Luc University Clinics, Belgium
Department of Neuroscience, University in Ottignies-Louvain-la-Neuve, Belgium
Department of Radiology, Massachusetts General Hospital, USA
Department of Clinical Biology, CHU UCL Namur, Belgium
Department of Geriatric Medicine, CHU UCL Namur, Belgium
Institute Health and Society, UCLouvain, Belgium

^*Correspondance to: François-Xavier Sibille 

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Abstract:

Background: Lymphomatosis cerebri (LC) is a rare variant of Primary Central Nervous System Lymphoma (PCNSL). This unusual presentation differs from systemic lymphoma or intravascular CNS lymphoma. It is often misdiagnosed, leading to delayed diagnosis and treatment. As the literature contains only case reports and small case series, it has not been adequately characterized. Case Report: We present the history of an 85-year-old man with a recent history of bilateral facial palsy. He was admitted with a rapidly progressive cognitive impairment not consistent with delirium. Diagnosis of LC was based on magnetic resonance imaging and cerebrospinal fluid analysis. Due to the patient’s poor health status, biopsy was not performed. He passed away two weeks later. Conclusion: To avoid misdiagnosis and delayed treatment of LC, multiple CSF analysis should be performed.

Keywords:

Lymphomatosis cerebri; Cognitive decline; Facial palsy

Cite the Article:

Waltener M, Hanseeuw B, Benjamin L, Hugues J, Sibille FX. Bilateral Facial Palsy and Rapid Cognitive Decline Indicating Lymphomatosis cerebri: A Case Report. Clin Case Rep Int. 2022; 6: 1383.