Clin Case Rep Int | Volume 7, Issue 1 | Case Report | Open Access
Núñez-Cruz JM1, Casanova-Rama A1, López-Brotons M1, Milla-Olaya B1, Martín-Benlloch S1, Brotons-Bañón E1, Seguí-Pérez C4, López-Corbalán JC3, Seguí-Pérez M6, Martínez-Caballero A5, Orozco-Beltrán D2,7 and Seguí-Ripoll JM1,2*
1Internal Medicine Service, San Juan University Hospital, Spain
2Department of Clinical Medicine, Medical School, University Miguel Hernández de Elche, Spain
3Government Sub-delegation, Alicante Immunization Center, Spain
4Veterinary School, University Cardenal Herrera, Spain
5Nuclear Medicine Service, San Juan University Hospital, Spain
6School of the Marist Brothers of Alicante, Spain
7Primary Care Medicine, Cabo Huertas Health Center, Spain
*Correspondance to: Seguí-Ripoll JMFulltext PDF
SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is a rare, heterogeneous, chronic autoinflammatory disease characterized by dermatological and osteoarticular clinical manifestations affecting multiple regions. Systemic manifestations are rare. We present the case of a middle-aged man with polyarthralgia and constitutional syndrome under study. He underwent diagnostic imaging tests that helped establish the differential diagnosis as SAPHO syndrome without skin involvement. To our knowledge, this is the first reported case of SAPHO syndrome that debuted as a constitutional condition, and this syndrome should be considered in the diagnostic spectrum.
Núñez-Cruz JM, Casanova-Rama A, López-Brotons M, Milla-Olaya B, Martín-Benlloch S, Brotons-Bañón E, et al. Constitutional Syndrome: First Case Reported as a Debut of Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis Syndrome. Clin Case Rep Int. 2023; 7: 1457.