Journal Basic Info
- Impact Factor: 0.285**
- H-Index: 6
- ISSN: 2638-4558
- DOI: 10.25107/2638-4558
Major Scope
- Virology
- Sleep Medicine and Disorders
- Allergy & Immunology
- Radiation Oncology
- Obstetrics and Gynecology
- Pathology
- Breast Neoplasms
- Internal Medicine
Abstract
Citation: Clin Case Rep Int. 2018;2(1):1072.DOI: 10.25107/2638-4558.1072
Epileptic Seizures and Clozapine Titration
Jaafar Nakhli, Aida Taieb, Selma Ben Nasr and Saad Saguem
Department of Psychiatry, Farhat Hached University Hospital, Tunisia
Department of Biophysics, Medical University, Tunisia
*Correspondance to: Jaafar Nakhli
PDF Full Text Short Communication | Open Access
Abstract:
Patients with resistant schizophrenia are commonly treated with Clozapine. They can develop epileptic seizure. In a sample of 62 resistant schizophrenia patients, five of them (8%) had developed Tonic-clonic and myoclonic seizures with EEG abnormalities.There were no difference in sociodemographic and clinical factors and daily intake Clozapine dose between patients with epileptic seizure and those without.Plasma Clozapine concentrations were higher in patients with epileptic seizures (1040 ng/ml vs. 640 ng/ml) (p<10-3). No differences were established for Plasma Norclozapine concentration between the two groups.Norclozapine/Clozapine Ratio were lower in patients with epileptic seizures at first day and after 15 days (p=0.006 and 0.024).
Keywords:
Cite the Article:
Nakhli J, Taieb A, Nasr SB, Saguem S. Epileptic Seizures and Clozapine Titration. Clin Case Rep Int. 2018; 2: 1072.
